Advanced Growth Factor Delivery Systems in Wound Management and Skin Regeneration
نویسندگان
چکیده
منابع مشابه
Advanced Growth Factor Delivery Systems in Wound Management and Skin Regeneration.
Growth factors are endogenous signaling molecules that regulate cellular responses required for wound healing processes such as migration, proliferation, and differentiation. However, exogenous application of growth factors has limited effectiveness in clinical settings due to their low in vivo stability, restricted absorption through skin around wound lesions, elimination by exudation prior to...
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The rise in lower extremity amputations due to nonhealing of foot ulcers in diabetic patients calls for rapid improvement in effective treatment regimens. Administration of growth factors (GFs) are thought to offer an off-the-shelf treatment; however, the dose- and time-dependent efficacy of the GFs together with the hostile environment of diabetic wound beds impose a major hindrance in the sel...
متن کاملContinuous epidermal growth factor delivery in corneal epithelial wound healing.
PURPOSE To investigate the effects of a single prolonged exposure to recombinant epidermal growth factor on the healing of anterior keratotomy wounds in New Zealand white rabbits. METHODS After wounding, eyes were perfused for 1, 2, 4, and 8 hours with either epidermal growth factor solution at a concentration of 50 micrograms/ml or balanced saline solution using a Morgan therapeutic lens (Mo...
متن کاملAdvanced Wound Management
Wounds may fail to heal because tension, infection, hematoma or seroma formation, ischemia, molestation, pressure, motion, foreign materials, neoplasia, drugs (corticosteroids, neoplasia), radiation, severe malnutrition, or underlying metabolic disease. When wounds fail to heal, the veterinarian should examine and treat the animal for underlying disease, culture a punch biopsy of the wound to e...
متن کاملTAT-Mediated Acidic Fibroblast Growth Factor Delivery to the Dermis Improves Wound Healing of Deep Skin Tissue in Rat
BACKGROUND The definition of deep tissue injury was derived from multiple clinical cases as "A purple or maroon localized area of discolored intact skin or blood-filled blister due to damage of underlying soft tissue from pressure and/or shear". Acidic fibroblast growth factor (aFGF) significantly improves wound healing under diabetic conditions. However, to date, the therapeutic application of...
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ژورنال
عنوان ژورنال: Molecules
سال: 2017
ISSN: 1420-3049
DOI: 10.3390/molecules22081259